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TCL1 MTCP1 protein domain : ウィキペディア英語版 | TCL1 MTCP1 protein domain
In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 (SWISSPROT ) and Protein p13 MTCP-1 encoded by MTCP-1 (SWISSPROT ). These are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. ==Function== Enhances the phosphorylation and activation of Akt. Once Akt is activated this will in turn trigger cell survival. Further more it helps to stabilise mitochondrial membrane potential.〔 〕〔 〕
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「TCL1 MTCP1 protein domain」の詳細全文を読む
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